If you are arriving by car, you can arrive by highway. Seville is perfectly joined by highway to other main cities inSpain, especially Andalusia and Portugal. Since 1992 when Seville celebrated the Expo the highways have become just as important as the rest of the big cities in Spain.
In Andalusia to arrive by highway to Seville or Huelva for example is easy. The road that takes you to Portugal is the A49 Quinto Centenario. If you would like to visit Granada and Almeria you would take the A92. If you're visiting Jerez or Cadiz the AP4 or A 4 will also connect you, as well as to Madrid. If you're trying to surround Seville you can take the SE 30 which is the highway that borders the city.
Besides that, Seville is a city that has two bus stations, the one Plaza de ARmas as well as the one in Prado de San Sebastian. Both connect the city with other andalusian cities, national cities, Portugal and Europe.
By car or bus, to arrive by highway to Seville is not a complicated manner.
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